BRCT Domain - Brct Domain

BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins.

The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage, for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.

Examples

Proteins, levels of Structure, Non-covalent Forces, excerpt 2 | MIT 7.01SC Fundamentals of Biology - Instructor: Graham Walker View the complete course: http://ocw.mit.edu/7-01SCF11 Professor Walker explains the categories of amino acids, the levels of protein structure, the bonds and forces...

Human proteins containing this domain include:

• BARD1; BRCA1
• CTDP1; TDT or DNTT
• ECT2
• LIG4
• MCPH1; MDC1
• NBN
• PARP1; PARP4; PAXIP1; PES1
• REV1; RFC1; TOPBP1; TP53BP1; XRCC1

References

PDB 2xnh gallery ‹ Protein Data Bank in Europe (PDBe) ‹ EMBL-EBI. Source : www.ebi.ac.uk

External links

Extending the Interaction Repertoire of FHA and BRCT Domains .... Source : www.intechopen.com

• Eukaryotic Linear Motif resource motif class LIG_BRCT_BRCA1_1
• Eukaryotic Linear Motif resource motif class LIG_BRCT_BRCA1_2
• Eukaryotic Linear Motif resource motif class LIG_BRCT_MDC1_1

This article incorporates text from the public domain Pfam and InterPro IPR001357

Identification of a Putative Novel Binding Site in BRCA1 BRCT .... Source : www.researchgate.net